Réaction #94840

Équation de réaction

phenyl isothiocyanate

triethylamine

1,3-dimethyl-2-imino-imidazolidine hydrobromide

→

N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea

Solvants

chloroform

chloroform

Conditions de réaction

Traitement

1. 1
   Températurethe reaction mixture is refluxed for 15 hours
2. 2
   TempératureAfter cooling
3. 3
   Lavageit is washed with water
4. 4
   Séchagedried over sodium sulfate
5. 5
   Autreevaporated in vacuo

Mode opératoire

30.4 g (0.3 mol) of triethylamine are added to a suspension of 58.2 g (0.3 mol) of 1,3-dimethyl-2-imino-imidazolidine hydrobromide in 470 ml of chloroform, at 5°, with stirring. A solution of 40.6 g (0.3 mol) of phenyl isothiocyanate in 235 ml of chloroform is then added dropwise and the reaction mixture is refluxed for 15 hours. After cooling, it is washed with water, dried over sodium sulfate and evaporated in vacuo. Crude N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea is obtained and after recrystallisation from ethanol this melts at 195°-196°.

Source