Réaction #945

Équation de réaction

benzaldehyde

product

Ethyl 2-aminobutyrate hydrochloride

magnesium sulphate

triethylamine

→

desired product

Rendement 88.9%

Ethyl 2-benzylideneaminobutyrate

Rendement 88.9%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   Filtrationthen filtered
2. 2
   ConcentrationThe filtrate was concentrated
3. 3
   Autretriturated in diethyl ether
4. 4
   Filtrationfiltered
5. 5
   Concentrationconcentrated

Mode opératoire

A solution of the product from step (a) (149.6 g), magnesium sulphate (74.3 g), and triethylamine (246 ml) in dichloromethane (1500 ml) was stirred at room temperature under nitrogen and benzaldehyde (94.9 g, Aldrich) was added dropwise. The mixture was stirred at room temperature for 3 hours then filtered. The filtrate was concentrated, triturated in diethyl ether, filtered and concentrated to yield the desired product as a yellow oil (174 g). 1H NMR consistent with the proposed structure.

Source