Réaction #94422

Équation de réaction

4,7-dihydro-4,7-dioxo-2-ethoxycarbonyl-6-hydroxy-1H-cyclohepta[b]pyridine-1-acetic acid ethyl ester

potassium hydroxide

Hydrochloric acid

→

title compound

2-Carboxy-4,7-dihydro-4,7-dioxo-6-hydroxy-1H-cyclopenta[b]pyridine-1-acetic Acid

Conditions de réaction

Traitement

1. 1
   AutreThe precipitate is collected
2. 2
   Lavagewashed with water, acetone and ether

Mode opératoire

A mixture of 4,7-dihydro-4,7-dioxo-2-ethoxycarbonyl-6-hydroxy-1H-cyclohepta[b]pyridine-1-acetic acid ethyl ester (1.7 g, described in Example 15) and 1N potassium hydroxide (12 ml) is stirred at room temperature for 2.5 hr. Hydrochloric acid (19%) is added until the mixture is acidic. The precipitate is collected and washed with water, acetone and ether to obtain the title compound, mp > 270° C.

Source