Réaction #94330

ord-16fb396343c44056b7ac1f4c8a16d892

Équation de réaction

[Na+].[OH-]
sodium hydroxide
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O.O.O.O
ampicillin trihydrate
→
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[Na+]
sodium ampicillin
Rendement 98.7%

Réactifs

[Na+].[OH-]
sodium hydroxide
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O.O.O.O
ampicillin trihydrate

Réactifs

Aucun

Solvants

O
water

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Températurewhile cooling
  2. 2
    FiltrationThe resulting clear solution was immediately sterile-filtered
  3. 3
    Filtrationfiltered
  4. 4
    Autreto remove
  5. 5
    Températurefrozen in bulk by the shell-freezing process

Mode opératoire

6 ml of an aqueous 1N sodium hydroxide solution (6 millimols of NaOH) which had been cooled to about 0° C. was added dropwise over a period of 5 minutes to a suspension of 2.42 gm (6 millimols) of ampicillin trihydrate in 24 ml of water at about 0° C., while cooling and vigorously stirring. The resulting clear solution was immediately sterile-filtered, that is, filtered to remove suspended particles, and the filtrate was without delay frozen in bulk by the shell-freezing process. Thereafter, the frozen filtrate was lyophilized, yielding 2.2 gm of white sodium ampicillin having a residual moisture content of 1.35% by weight and a microbiological activity of 94% (U.S.P. standard).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US04130558uspto-grants-1978_12