Réaction #94017

Équation de réaction

5-(Dimethylamino)methyl-2-furanmethanol

cysteamine hydrochloride

sodium carbonate

→

2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine

Rendement 54.2%

Solvants

hydrochloric acid

Conditions de réaction

Traitement

1. 1
   Extractionthe resultant solid extracted with diethyl ether
2. 2
   AutreRemoval of solvent
3. 3
   workup.DISTILLATIONfollowed by distillation of the residue

Mode opératoire

5-(Dimethylamino)methyl-2-furanmethanol (15.5 g) was added dropwise to a stirred, ice-cold solution of cysteamine hydrochloride (11.36 g) in concentrated hydrochloric acid (40 ml). After standing at 0° for 18 hr, excess anhydrous sodium carbonate was added and the resultant solid extracted with diethyl ether. Removal of solvent followed by distillation of the residue gave 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine (11.6 g) b.p. 104-106° (0.1 mm). Picrate salt m.p. 142-144°.

Source