Réaction #937948

Équation de réaction

10-bromo-2-hydroxy-4H-pyrido[3,2,1-jk]carbazole-4-one

potassium carbonate

i-propyl bromoacetate

potassium iodide

→

title compound

Rendement 51.0%

10-bromo-2-i-propoxycarbonylmethyloxy-4H-pyrido[3,2,1-jk]carbazole-4-one

Rendement 51.0%

Solvants

dimethyl sulfoxide

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGThe mixture was stirred at room temperature for 12 hours
2. 2
   Autrethe crystals precipitated
3. 3
   Filtrationwere recovered by filtration
4. 4
   AutreThe crude crystals were purified by silica gel flash column chromatography (eluent: methylene chloride containing 1% methanol)

Mode opératoire

10-bromo-2-hydroxy-4H-pyrido[3,2,1-jk]carbazole-4-one (3 g) obtained in Example 59 was suspended in dimethyl sulfoxide (120 ml), and potassium carbonate (2.6 g) was added to the suspension. The mixture was stirred at room temperature for 30 minutes and i-propyl bromoacetate (1.4 ml) and potassium iodide (1 grain) were added in succession to the mixture. The mixture was stirred at room temperature for 12 hours, and the reaction mixture was poured into ice water (500 ml), and the crystals precipitated were recovered by filtration. The crude crystals were purified by silica gel flash column chromatography (eluent: methylene chloride containing 1% methanol) to obtain the title compound (2.0 g, 51%).

Source