Réaction #93768

ord-0abcb0c150bc4175a08041240e6ed897

Équation de réaction

CC(C)(C)C(O)C(=O)[O-].[Na+]
Sodium 3,3-dimethyl-2-hydroxybutyrate
[Na+].[O-]Cl
sodium hypochlorite
→
CC(C)(C)C(=O)C(=O)[O-].[Na+]
sodium 3,3-dimethyl-2-oxobutyrate

Réactifs

CC(C)(C)C(O)C(=O)[O-].[Na+]
Sodium 3,3-dimethyl-2-hydroxybutyrate
[Na+].[O-]Cl
sodium hypochlorite

Réactifs

O.[O]=[Ru]=[O]
ruthenium dioxide hydrate

Solvants

O
water

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    workup.ADDITIONis slowly added

Mode opératoire

Sodium 3,3-dimethyl-2-hydroxybutyrate and ruthenium dioxide hydrate are added to water, the pH rendered alkaline, and sodium hypochlorite is slowly added to produce sodium 3,3-dimethyl-2-oxobutyrate in high yield and purity. The solid catalyst is filtered off and may be re-used while the filtrate can be directly used in further synthesis.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US04614822uspto-grants-1986_09