Réaction #93138

Équation de réaction

2,6-dinitrobenzonitrile

piperidine

water

→

2-nitro-6-piperidinobenzonitrile

Solvants

dimethylformamide

Conditions de réaction

Traitement

1. 1
   Températurewhile externally cooling because of heat generation
2. 2
   Autrethe precipitate thus formed
3. 3
   Autrewas collected
4. 4
   Lavagewashed with water
5. 5
   Séchagewith methanol, and dried

Mode opératoire

5.8 g of 2,6-dinitrobenzonitrile was dissolved in 30 ml of dimethylformamide, and 10.2 ml of piperidine was added to the solution. The mixture was stirred at 50° C. for 30 minutes while externally cooling because of heat generation. The reaction mixture was poured into water, and the precipitate thus formed was collected, washed with water and then with methanol, and dried to obtain 6.7 of 2-nitro-6-piperidinobenzonitrile (melting point: 122°-123° C.).

Source