Réaction #92753

Équation de réaction

benzyl 4-({[8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl]carbonyl}amino)-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

→

methyl[4-({[8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl]carbonyl}amino)piperidin-4-yl]acetate

Rendement 97.7%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction mixture was filtered over Celite
2. 2
   Autrethe solvent was then evaporated under reduced pressure

Mode opératoire

To a solution of 1.2 g of benzyl 4-({[8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl]carbonyl}amino)-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate in 30 ml of methanol was added 300 mg of 10% palladium-carbon, followed by stirring overnight under a hydrogen atmosphere. The reaction mixture was filtered over Celite and the solvent was then evaporated under reduced pressure to obtain 900 mg of methyl[4-({[8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl]carbonyl}amino)piperidin-4-yl]acetate.

Source