Réaction #927248

Équation de réaction

1,1,2-tribromo-2-(7-hydroxyheptyl)cyclopropane

methyllithium

→

1-(7-hydroxyheptyl)-cyclopropene

Rendement 90.0%

Solvants

ether

Conditions de réaction

Traitement

1. 1
   AutreThe reaction was quenched with saturated ammonium chloride
2. 2
   LavageThe reaction mixture was washed with water and brine
3. 3
   Séchagedried over magnesium sulfate
4. 4
   Filtrationfiltered

Mode opératoire

A solution of 1.0 g 1,1,2-tribromo-2-(7-hydroxyheptyl)cyclopropane (2.5 mmol) in 25 ml of ether was treated at −78° C. with 7.2 ml of methyllithium (1.4 M, 10 mmol). After 5 minutes, the reaction mixture was warmed to 0° C. and held at this temperature. The reaction was quenched with saturated ammonium chloride. The reaction mixture was washed with water and brine, dried over magnesium sulfate, filtered and stripped to give 240 mg of 1-(7-hydroxyheptyl)-cyclopropene (90% purity).

Source