Réaction #92681

Équation de réaction

chloroform

water

methyl 3-cyclopropyl-3-oxopropanoate

sulfuryl chloride

→

methyl 2-chloro-3-cyclopropyl-3-oxopropanoate

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   Températurecooling
2. 2
   Températurecooling
3. 3
   Autrea layer separation operation
4. 4
   LavageThe organic layer was washed with saturated brine
5. 5
   Séchagedried over anhydrous sodium sulfate
6. 6
   Autrethe solvent was evaporated under reduced pressure

Mode opératoire

To a solution of 2 g of methyl 3-cyclopropyl-3-oxopropanoate in 20 ml of dichloromethane was added dropwise 1.24 ml of sulfuryl chloride under ice-cooling, followed by stirring at room temperature for 5 hours. To the reaction mixture was added water under ice-cooling, and chloroform was further added thereto to carry out a layer separation operation. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain 2.48 g of methyl 2-chloro-3-cyclopropyl-3-oxopropanoate.

Source