Réaction #9160

ord-e8415c5d0b5f45968db469e1e4e5f5f1

Équation de réaction

Cc1cccc2[nH]ccc12
4-methyl-1H-indole
C[N+](C)=Cc1ccc(F)cc1.[Cl-]
(4-fluoro-benzylidene)-dimethylammonium chloride
O=Cc1ccc(F)cc1
4-fluoro-benzaldehyde
CNC
dimethylamine
Cc1cccc2[nH]cc(C(c3ccc(F)cc3)N(C)C)c12
[(4-Fluoro-phenyl)-(4-methyl-1H-indol-3-yl)-methyl]-dimethyl-amine

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The preparation was carried out in accordance with general synthesis instructions 4 from 4-methyl-1H-indole and (4-fluoro-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 4-fluoro-benzaldehyde and dimethylamine.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07091220B2uspto-grants-2006_08