Réaction #91563

Équation de réaction

1,1-dimethylethyl 7-(5-acetyl-2-{[(4-methyl-2-pyridinyl)methyl]oxy}phenyl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

hydrogen chloride

→

title compound

1-[4-{[(4-methyl-2-pyridinyl)methyl]oxy}-3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)phenyl]ethanone

Solvants

dioxane

Conditions de réaction

Traitement

1. 1
   AutreOn completion the solid formed
2. 2
   Filtrationwas collected by filtration
3. 3
   Lavagewashed with acetone
4. 4
   workup.DISSOLUTIONThe solid was then dissolved in water
5. 5
   AutreSolid was obtained which
6. 6
   Filtrationwas collected by filtration
7. 7
   AutreThis was triturated with diethyl ether

Mode opératoire

1,1-dimethylethyl 7-(5-acetyl-2-{[(4-methyl-2-pyridinyl)methyl]oxy}phenyl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (3.0 g) was dissolved in dioxane (20 ml). Gaseous hydrogen chloride was passed through the reaction mixture for 1.5 h. The reaction was monitored by TLC. On completion the solid formed was collected by filtration and washed with acetone. The solid was then dissolved in water and the mixture neutralised with aqueous sodium hydroxide (1M). Solid was obtained which was collected by filtration. This was triturated with diethyl ether to yield the title compound, 2.1 g (88%).

Source