Réaction #91282

Équation de réaction

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine

3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester

→

title compound

Rendement 71.0%

3-[3-chloro-4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-propionic acid

Rendement 71.0%

Conditions de réaction

Traitement

1. 1
   Autreto react sequentially in the same manner as in Steps A and B of Example 1

Mode opératoire

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine (46 mg, 0.20 mmol) obtained in Step C of Preparation Example 27 and 3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester (51 mg, 0.22 mmol) obtained in Step C of Preparation Example 42 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (45 mg, 71%).

Source