Réaction #91271

Équation de réaction

3-Chloromethyl-2-cyclopentylsulfanyl-pyridine

(5,7-difluoro-6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester

→

title compound

Rendement 83.4%

[6-(2-cyclopentylsulfanyl-pyridin-3-ylmethoxy)-5,7-difluoro-benzofuran-3-yl]-acetic acid

Rendement 83.4%

Conditions de réaction

Traitement

1. 1
   Autreto react sequentially in the same manner as in Steps A and B of Example 1

Mode opératoire

3-Chloromethyl-2-cyclopentylsulfanyl-pyridine (19 mg, 0.08 mmol) obtained in Step C of Preparation Example 8 and (5,7-difluoro-6-hydroxy-benzofuran-3-yl)-acetic acid methyl ester (20 mg, 0.08 mmol) obtained in Step C of Preparation Example 50 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (28 mg, 81%).

Source