Réaction #91237

Équation de réaction

3-Chloromethyl-2-cyclopentylsulfanyl-pyridine

((S)-6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester

→

title compound

Rendement 70.0%

[(S)-6-(2-cyclopentylsulfanyl-pyridin-3-ylmethoxy)-2,3-dihydro-benzofuran-3-yl]-acetic acid

Rendement 70.0%

Conditions de réaction

Traitement

1. 1
   Autreobtained in Preparation Example 56
2. 2
   Autreto react sequentially in the same manner as in Steps A and B of Example 1

Mode opératoire

3-Chloromethyl-2-cyclopentylsulfanyl-pyridine (11 mg, 0.05 mmol) obtained in Step C of Preparation Example 8 and ((S)-6-hydroxy-2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester (10 mg, 0.05 mmol) obtained in Preparation Example 56 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (13 mg, 70%).

Source