Réaction #91217

Équation de réaction

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine

2-(3,5-difluoro-4-hydroxy-phenyl)-cyclopropanecarboxylic acid ethyl ester

→

title compound

Rendement 77.6%

2-[4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-3,5-difluoro-phenyl]-cyclopropane carboxylic acid

Rendement 77.6%

Conditions de réaction

Traitement

1. 1
   Autreto react sequentially in the same manner as in Steps A and B of Example 1

Mode opératoire

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine (0.033 g, 0.143 mmol) obtained in Step C of Preparation Example 27 and 2-(3,5-difluoro-4-hydroxy-phenyl)-cyclopropanecarboxylic acid ethyl ester (0.033 g, 0.143 mmol) obtained in Step B of Preparation Example 31 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.045 g, 77%).

Source