Réaction #91124

Équation de réaction

(2-Cyclopentylsulfanyl-pyridin-3-yl)-methanol

(2-cyclopentylsulfanyl-pyridin-3-yl)-methanol

SOCl2

→

title compound

3-chloromethyl-2-cyclopentylsulfanyl-pyridine

Solvants

CH3CN

Conditions de réaction

Traitement

1. 1
   Autreat 0° C
2. 2
   AutreAfter the termination of the reaction
3. 3
   Concentrationthe reactant was concentrated under reduced pressure

Mode opératoire

(2-Cyclopentylsulfanyl-pyridin-3-yl)-methanol (0.6 g, 2.87 mmol) obtained in Step B was dissolved in CH3CN (5 mL), and SOCl2(0.42 mL, 5.74 mmol) was added thereto at 0° C. The mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure to obtain the title compound, which was used in the next step without a separate purification process.

Source