Réaction #90806

Équation de réaction

5-fluoro-N-methyl-2-nitrobenzamide

1-(2-hydroxyethyl)piperazine

Hunig's base

→

5-[4-(2-Hydroxyethyl)-1-piperazinyl]-N-methyl-2-nitrobenzamide

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   Autrethe residue was purified by flash column

Mode opératoire

A solution of 5-fluoro-N-methyl-2-nitrobenzamide, 1-(2-hydroxyethyl)piperazine, and Hunig's base in 20 mL of DMF was stirred at room temperature over the weekend. The resulting mixture was rotavaped to dryness, and the residue was purified by flash column SF40-150 at 2%-10% MeOH/CH2Cl2. Product came out at 7% MeOH/CH2Cl2. MS(ES) m/e 309 [M+H].

Source