Réaction #90191

Équation de réaction

1-(2-bromo-4-methoxyphenyl)-ethanone

MeMgBr

ammonium chloride

→

title compound

Rendement 69.0%

2-(2-Bromo-4-methoxy-phenyl)-propan-2-ol

Rendement 69.0%

Solvants

THF

Conditions de réaction

Traitement

1. 1
   Extractionextracted with ethyl acetate
2. 2
   LavageThe organic layer was washed with saturated brine
3. 3
   Autrethe residues obtained
4. 4
   Concentrationafter concentration under reduced pressure
5. 5
   Autrewere purified by silica gel column (ethyl acetate/hexane)

Mode opératoire

To the mixture of 1-(2-bromo-4-methoxyphenyl)-ethanone (300 mg) dissolved in THF solution (3 ml), MeMgBr (3 M THF solution, 0.52 ml) was added at 0° C. under nitrogen atmosphere. Then, the mixture was stirred at room temperature for 6 hrs. The reaction mixture was added with saturated aqueous solution of ammonium chloride and extracted with ethyl acetate. The organic layer was washed with saturated brine, and the residues obtained after concentration under reduced pressure were purified by silica gel column (ethyl acetate/hexane) to obtain the title compound (220 mg, 69%).

Source