Réaction #89730

Équation de réaction

Lithium hexamethyldisilazide

1-benzyl 4-methyl(2S)-2-[benzyl((2R)-2-(1-ethoxyethoxy)-3-[(4-methylphenyl)sulfonyl]oxypropyl)amino]succinate

toluene

→

product

Rendement 78.2%

2-benzyl 3-methyl(2S,3S,5S)-1-benzyl-5-(1-ethoxyethoxy)piperidine-2,3-dicarboxylate

Rendement 78.2%

Solvants

tetrahydrofuran

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   Températureto warm up to at 0 Celsius gradually
2. 2
   workup.STIRRINGstirred at 0 Celsius for 30 min
3. 3
   AutreAfter quenched with aq ammonium chloride
4. 4
   Extractionthe mixture was extracted with ethyl acetate
5. 5
   LavageThe combined organic layers were washed with water, brine
6. 6
   Séchagedried (sodium sulfate)
7. 7
   Concentrationconcentrated
8. 8
   Autreto dry
9. 9
   AutreThe residue was purified on silica gel column
10. 10
    Lavageeluting with 0 to 20% EtOAc in hexane

Mode opératoire

To a solution of 1-benzyl 4-methyl(2S)-2-[benzyl((2R)-2-(1-ethoxyethoxy)-3-[(4-methylphenyl)sulfonyl]oxypropyl)amino]succinate (34.30 g, 0.05464 mol) in a mixture of tetrahydrofuran (90.0 mL, 1.11 mol) and toluene (470.0 mL, 4.412 mol) at −78 Celsius was added 1.00 M of Lithium hexamethyldisilazide in tetrahydrofuran (65.6 mL). The resulting mixture was stirred at −78 Celsius overnight, and then allowed to warm up to at 0 Celsius gradually and stirred at 0 Celsius for 30 min. After quenched with aq ammonium chloride, the mixture was extracted with ethyl acetate. The combined organic layers were washed with water, brine, and dried (sodium sulfate), and concentrated to dry. The residue was purified on silica gel column, eluting with 0 to 20% EtOAc in hexane, to yield the cyclized product (19.47 g, 78.2%). MS (ESI): (M+H)+=456.0.

Source