Réaction #88400

Équation de réaction

sodium hydroxide

methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate

→

title compound

sodium 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Autreobtained in (Example 2.2) <Step 1>
2. 2
   Températurethe obtained mixture was then heated
3. 3
   Températureto reflux for 15 minutes
4. 4
   workup.DISTILLATIONThereafter, the solvent was distilled away under reduced pressure

Mode opératoire

An aqueous solution (1 ml) of sodium hydroxide (9.6 mg) was added to a methanol (1 ml) solution of the methyl 4-(4,5-dimethylthiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxylate (30 mg) obtained in (Example 2.2) <Step 1>, and the obtained mixture was then heated to reflux for 15 minutes. Thereafter, the solvent was distilled away under reduced pressure, and the residue was then subjected to azeotropy with toluene, so as to obtain a crude product of the title compound.

Source