Réaction #8796

Équation de réaction

4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine

sodium hydride

5-piperidino-1-pentanol

→

4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine

Solvants

cyclohexane

Conditions de réaction

Traitement

1. 1
   Températureunder reflux for 4 hours

Mode opératoire

13.8 kg of 4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine, 4.8 kg of 60% sodium hydride, 130 kg of cyclohexane and 10.6 kg of 5-piperidino-1-pentanol were stirred under reflux for 4 hours.

Source