Réaction #87602

Équation de réaction

2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid

HCl

→

5-(aminomethyl)-2-chlorobenzoic acid hydrochloride

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture was refluxed for 18 h
2. 2
   ConcentrationThe reaction mixture was concentrated
3. 3
   Autrecrude reaction mixture

Mode opératoire

To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.

Source