Réaction #87553

Équation de réaction

1-(difluoromethyl)-3-nitrobenzene

HCl

→

desired product

Rendement 97.8%

3-(difluoromethyl)aniline

Rendement 97.8%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe title compound was prepared

Mode opératoire

The title compound was prepared according to the procedure described in step-2 of Intermediate-28 by using 1-(difluoromethyl)-3-nitrobenzene (1.0 g, 5.0 mmol), Iron powder (3.0 g, 15.0 mmol), conc. HCl (5 mL) and methanol (20 mL) to afford 0.700 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 5.36 (br s, 2H), 6.62-6.82 (m, 4H), 7.11 (t, J=7.8 Hz, 1H); MS (m/z): 144.05 (M+H)+.

Source