Réaction #86594

Équation de réaction

benzyl-1-(2-(2-ethylbutylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl-carbamate

→

2-(3-Amino-2-oxopyridin-1(2H)-yl)-N-(2-ethylbutyl)acetamide

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe catalysis is separated by filtration over silica gel, before the solvent
2. 2
   Autreis removed in vacuo
3. 3
   AutreDark oil is obtained
4. 4
   Autreit is suitable for further processing without further purification

Mode opératoire

5.22 g of benzyl-1-(2-(2-ethylbutylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl-carbamate (2.4, ˜11.2 mmol) are dissolved under nitrogen atmosphere in 60 mL of methanol. To this solution, 500 mg of Pd/C (10%) are added and stirred under hydrogen atmosphere at atmosphere pressure for 2.5 h. The catalysis is separated by filtration over silica gel, before the solvent is removed in vacuo. Dark oil is obtained and it is suitable for further processing without further purification.

Source