Réaction #85941

Équation de réaction

sodium carbonate

ammonium acetate

ethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-imidazol-2-carboxylate

Ethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-imidazole-2-carboxylate

→

6-(2,4-Dichlorophenyl)imidazo[1,2-a]pyrazin-8(7H)-one

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Températureunder reflux for 12 h
2. 2
   FiltrationThe precipitate was filtered off
3. 3
   Autredried under high vacuum

Mode opératoire

920 mg (2.8 mmol) of ethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-imidazol-2-carboxylate (Example 3A) were dissolved in 45 ml of glacial acetic acid, and 2.17 g (28 mmol) of ammonium acetate were added. The mixture was stirred under reflux for 12 h. The reaction mixture was added to ice-water and neutralized and with sodium carbonate. The precipitate was filtered off and dried under high vacuum. This gave 650 mg (82% of theory) of the product as a solid.

Source