Réaction #85886

Équation de réaction

7-chloro-5-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)pyrido[4,3-b]pyrazine

4-morpholinophenylboronic acid

Cs2CO3

→

title compound

4-(4-(5-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)pyrido[4,3-b]pyrazin-7-yl)phenyl)morpholine

Solvants

dioxane

Conditions de réaction

Traitement

1. 1
   Autrewas sealed in a microwave reaction cube
2. 2
   Températurecooled to ambient temperature
3. 3
   Concentrationconcentrated under reduced pressure
4. 4
   Autrethe residue was purified by chromatography

Mode opératoire

A mixture of 7-chloro-5-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)pyrido[4,3-b]pyrazine (47 mg, 0.17 mmol), 4-morpholinophenylboronic acid (105 mg, 0.51 mmol), and PdCl2(dppf) (10 mg), Cs2CO3 (130 mg, 0.51 mmol) in dioxane (5 mL) was sealed in a microwave reaction cube, stirred at 180° C. for 60 minutes in a microwave reactor, cooled to ambient temperature, concentrated under reduced pressure, and the residue was purified by chromatography to give the title compound. MS (m/z): 403 (M+H)+.

Source