Réaction #8539

Équation de réaction

Ethyl 2-(2,3,4-trifluoroanilino)propionate

sodium hydroxide

→

title compound

Rendement 100.0%

2-(2,3,4-Trifluoroanilino)propionic acid

Rendement 100.0%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Autreat 0° C
2. 2
   Autrethe solvent was evaporated
3. 3
   workup.ADDITIONAfter adding water
4. 4
   Lavagethe residue was washed with chloroform
5. 5
   workup.ADDITIONNext, hydrochloric acid (6 mol/l) was slowly added to the aqueous layer until pH value
6. 6
   ExtractionThen the aqueous layer was extracted with IPE
7. 7
   SéchageThe organic layer was dried over anhydrous magnesium sulfate
8. 8
   Autrethe solvent was evaporated

Mode opératoire

Ethyl 2-(2,3,4-trifluoroanilino)propionate (2.47 g) was dissolved in ethanol (40 ml) and an aqueous solution (3 mol/l; 10 ml) of sodium hydroxide was slowly added thereto at 0° C. After stirring at room temperature for 3 hours, the solvent was evaporated. After adding water, the residue was washed with chloroform. Next, hydrochloric acid (6 mol/l) was slowly added to the aqueous layer until pH value reached 1. Then the aqueous layer was extracted with IPE. The organic layer was dried over anhydrous magnesium sulfate and then the solvent was evaporated to give the title compound (2.19 g) as colorless crystals. Various spectral data of this product was identical with those obtained in Example 23.

Source