Réaction #8536

Équation de réaction

2,3,4-Trifluoronitrobenzene

pyruvic acid

→

title compound

Rendement 96.0%

2-(2,3,4-Trifluoroanilino)propionic acid

Rendement 96.0%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Concentrationthe obtained filtrate was concentrated under reduced pressure

Mode opératoire

2,3,4-Trifluoronitrobenzene (1.01 g) and pyruvic acid (0.75 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 4.9 MPa (converted from 50 kgf/cm2) for 5 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.20 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Source