Réaction #8535

Équation de réaction

2,3,4-Trifluoronitrobenzene

pyruvic acid

→

title compound

Rendement 97.8%

2-(2,3,4-Trifluoroanilino)propionic acid

Rendement 97.8%

Solvants

IPA

Conditions de réaction

Traitement

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Concentrationthe obtained filtrate was concentrated under reduced pressure

Mode opératoire

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.09 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Source