Réaction #8531

Équation de réaction

hydrochloric acid

2,3,4-Trifluoronitrobenzene

ethyl pyruvate

→

title compound

Rendement 97.9%

Ethyl 2-(2,3,4-trifluoroanilino)propionate

Rendement 97.9%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Concentrationthe obtained filtrate was concentrated under reduced pressure

Mode opératoire

2,3,4-Trifluoronitrobenzene (1.01 g) and ethyl pyruvate (1.15 g) were dissolved in ethanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.38 g) was obtained as slightly yellow oily substance. Various spectral data of this product was identical with those obtained in Example 7.

Source