Réaction #8530

Équation de réaction

hydrochloric acid

2,3,4-Trifluoroaniline

methyl pyruvate

→

title compound

Rendement 81.8%

Methyl 2-(2,3,4-trifluoroanilino)propionate

Rendement 81.8%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   FiltrationAfter filtering off Pd—C
2. 2
   Concentrationthe obtained filtrate was concentrated under reduced pressure

Mode opératoire

2,3,4-Trifluoroaniline (1.01 g) and methyl pyruvate (0.87 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa (converted from 30 kgf/cm2) for 2 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.31 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

Source