Réaction #8527

Équation de réaction

hydrogen

2,3,4-Trifluoroaniline

methyl pyruvate

magnesium sulfate

→

title compound

Rendement 95.3%

Methyl 2-(2,3,4-trifluoroanilino)propionate

Rendement 95.3%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   FiltrationAfter filtering off Pd—C and magnesium sulfate
2. 2
   Concentrationthe obtained filtrate was concentrated under reduced pressure
3. 3
   AutreThe crystals thus precipitated
4. 4
   Filtrationwere filtered
5. 5
   Lavagewhile washing with hexane

Mode opératoire

2,3,4-Trifluoroaniline (2.94 g) and methyl pyruvate (2.04 g) were dissolved in methanol (30 ml). After adding 5% Pd—C (2.0 g) and anhydrous magnesium sulfate (2.65 g), the mixture was stirred at 50° C. in a hydrogen atmosphere for 16 hours. After filtering off Pd—C and magnesium sulfate, the obtained filtrate was concentrated under reduced pressure. The crystals thus precipitated were filtered while washing with hexane. Thus the title compound (4.44 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

Source