Réaction #8521

Équation de réaction

trifluoromethyl phenyl sulfone tBuOK

trifluoromethyl phenyl sulfone tBuOK

methyl benzoate

iodobenzene

2,2,2-trifluoroacetophenone

→

α,α,α-trifluorotoluene

Rendement 26.0%

Conditions de réaction

Traitement

1. 1
   Autreat about −50° C. to about −20° C

Mode opératoire

The trifluoromethyl phenyl sulfone/tBuOK trifluoromethylation method can also be applied to other systems. For instance, methyl benzoate can be trifluoromethylated to generate 2,2,2-trifluoroacetophenone in 30% yield at about −50° C. to about −20° C. CF3Cu can be in situ generated with trifluoromethyl phenyl sulfone/tBuOK and copper iodide (CuI), and then further react with iodobenzene at 80° C. for 20 h to give α,α,α-trifluorotoluene in 26% yield.

Source