Réaction #8490

Équation de réaction

5-fluoro-2-methylbenzonitrile

N-bromosuccinimide

→

product

Rendement 102.0%

2-Bromomethyl-5-fluorobenzonitrile

Rendement 102.0%

Solvants

carbon tetrachloride

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 18 h
2. 2
   Filtrationfiltered through fritted glass
3. 3
   LavageThe solid in the funnel was washed with carbon tetrachloride (3×50 mL)
4. 4
   Autreevaporated to dryness under vacuum

Mode opératoire

A mixture of 5-fluoro-2-methylbenzonitrile (10.0 g, 74.0 mmol), N-bromosuccinimide (NBS, 13.2 g, 74.0 mmol), benzoyl peroxide (0.2 g, 0.82 mmol), and carbon tetrachloride (100 mL) was refluxed for 18 h. The reaction mixture was then cooled to room temperature and filtered through fritted glass. The solid in the funnel was washed with carbon tetrachloride (3×50 mL) and evaporated to dryness under vacuum to provide 16.1 g, 102% yield of product.

Source