Réaction #8481

Équation de réaction

epichlorohydrin

product

2-[4-hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine

potassium hydroxide

→

title compound

2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

Solvants

dichloromethane

methanol

Conditions de réaction

Traitement

1. 1
   Filtrationfiltered
2. 2
   Lavagethe filtrate washed with water
3. 3
   Autredried
4. 4
   Filtrationsodium sulfate filtered
5. 5
   Autreevaporated

Mode opératoire

The product of Step B (27 g) in methanol (500 mL) was treated with potassium hydroxide (14 g) and stirred at ambient temperature for 2 hours. To this solution was then added epichlorohydrin (9.4 mL) and the mixture stirred for an additional 48 hours. The reaction mixture was diluted with dichloromethane, filtered and the filtrate washed with water, dried, sodium sulfate filtered and evaporated to afford the title compound (18.2 g).

Source