Réaction #84341

Équation de réaction

2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone

methoxyamine hydrochloride

→

desired product

Rendement 84.9%

2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone-O-methyloxime

Rendement 84.9%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   AutreAfter completion of the reaction
2. 2
   Autrethe solvent was evaporated under reduced pressure
3. 3
   Autrethe resulting residue was purified by silica gel column chromatography

Mode opératoire

To 1.3 g of 2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone in 10 ml of ethanol, 362 mg of methoxyamine hydrochloride was added, and the mixture was stirred at room temperature for 13 hours. After completion of the reaction, the solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 0:100 to 5:95) to obtain 1.2 g of the desired product as a colorless oil.

Source