Réaction #8425

ord-681a7360d8f647d892e600b37f148d04

Équation de réaction

CN1CCN(c2cccc3[nH]ccc23)CC1
4-(4-methyl-1-piperazinyl)-1H-indole
Cc1ccc(S(=O)(=O)Cl)cc1
p-methylbenzenesulfonyl chloride
→
Cc1ccc(S(=O)(=O)n2ccc3c(N4CCN(C)CC4)cccc32)cc1.Cl
title compound
Cc1ccc(S(=O)(=O)n2ccc3c(N4CCN(C)CC4)cccc32)cc1.Cl
4-(4-Methyl-1-piperazinyl)-1-(4-methylbenzenesulfonyl)-1H-indole hydrochloride

Réactifs

CN1CCN(c2cccc3[nH]ccc23)CC1
4-(4-methyl-1-piperazinyl)-1H-indole
Cc1ccc(S(=O)(=O)Cl)cc1
p-methylbenzenesulfonyl chloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound was prepared 4-(4-methyl-1-piperazinyl)-1H-indole and p-methylbenzenesulfonyl chloride according to Method 4 (45%): 1H NMR (CD3OD) δ 7.81–6.77 (m, 9H), 3.62–3.02 (m, 8H), 2.98 (s, 3H), 2.34 (s, 3H); MS (ESI) 370.5 (M+H)+; Purity (HPLC) >95%.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07087750B2uspto-grants-2006_08