Réaction #8424

Équation de réaction

4-(4-boc-piperazinyl)-indole

(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl chloride

→

title compound

1-[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]-4-(1-piperazinyl)-1H-indole hydrochloride

Conditions de réaction

Mode opératoire

The title compound was prepared 4-(4-boc-piperazinyl)-indole and 1-[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl chloride according to Method 4 to afford the hydrochloride salt (yield 45%), HPLC purity >95%; 1H NMR (DMSO-d6) δ 2.65 (s, 3H), 3.26 (bs, 8H), 6.82 (app d, 1H), 7.00 (appd, 1H), 7.28 (app t, 1H), 7.60 (app dd, 2H), 7.87 (app d, 1H), 8.08–8.12 (m, 2H); 13C NMR (DMSO-d6) δ 145.05, 139.82, 139.35, 137.46, 135.14, 133.31, 130.96, 128.70 (2C), 125.62, 124.89, 124.12, 123.52, 111.42, 107.91, 107.71, 47.87 (2C), 43.03 (2C), 12.27; MS (posES-FIA) m/z 446 (M+H).

Source