Réaction #8423

ord-59b619bc204548cba155922be20a2f11

Équation de réaction

CC(C)(C)OC(=O)N1CCN(c2cccc3[nH]ccc23)CC1
4-(4-boc-piperazinyl)-indole
CS(=O)(=O)c1ccccc1S(=O)(=O)Cl
2-methylsulfonyl-phenylsulfonyl chloride
→
CS(=O)(=O)c1ccccc1S(=O)(=O)n1ccc2c(N3CCNCC3)cccc21.Cl
title compound
CS(=O)(=O)c1ccccc1S(=O)(=O)n1ccc2c(N3CCNCC3)cccc21.Cl
Methyl 2-{[4-(1-piperazinyl)-1H-indol-1-yl]sulfonyl}phenyl sulfone hydrochloride

Réactifs

CC(C)(C)OC(=O)N1CCN(c2cccc3[nH]ccc23)CC1
4-(4-boc-piperazinyl)-indole
CS(=O)(=O)c1ccccc1S(=O)(=O)Cl
2-methylsulfonyl-phenylsulfonyl chloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 2-methylsulfonyl-phenylsulfonyl chloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.22 (br, 1 H), 8.29 (d, J=-8 Hz, 1 H), 7.99 (t, J=8 Hz, 1 H), 7.90–7.80 (m, 2 H), 7.43 (d, J=8 Hz, 1 H), 7.3 0–7.15 (m, 2 H), 7.04 (d, J=3 Hz, 1 H), 6.85 (d, J=8 Hz, 1 H), 3.56 (s, 3 H), 3.29 (m, 8 H); MS (ESI+) for m/z 420 (M+H)+.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07087750B2uspto-grants-2006_08