Réaction #8417

ord-d86cc93f907f48b381a9d7bc63bf7406

Équation de réaction

CC(C)(C)OC(=O)N1CCN(c2cccc3[nH]ccc23)CC1
4-(4-boc-piperazinyl)-indole
O=S(=O)(Cl)c1ccc(F)cc1F
2,4-di-fluorophenylsulfonylchloride
→
Cl.O=S(=O)(c1ccc(F)cc1F)n1ccc2c(N3CCNCC3)cccc21
title compound
Cl.O=S(=O)(c1ccc(F)cc1F)n1ccc2c(N3CCNCC3)cccc21
1-[(2,4-Difluorophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole Hydrochloride

Réactifs

CC(C)(C)OC(=O)N1CCN(c2cccc3[nH]ccc23)CC1
4-(4-boc-piperazinyl)-indole
O=S(=O)(Cl)c1ccc(F)cc1F
2,4-di-fluorophenylsulfonylchloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound was prepared from 4-(4-boc-piperazinyl)-indole and 2,4-di-fluorophenylsulfonylchloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.41 (br, 1 H), 8.24 (m, 1 H), 7.75 (m, 1 H), 7.58 (m, 1 H), 7.47–7.33 (m, 2 H), 7.23 (t, J=8 Hz, 1 H), 6.99 (d, J=5 Hz, 1 H), 6.70 (d, J -8 Hz, 1 H), 3.25 (m, 8 H). MS (ESI+) for m/z 378 (M+H)+.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07087750B2uspto-grants-2006_08