Réaction #8414

ord-0dd7577b1cbb45b08b04256982872821

Équation de réaction

CC(C)(C)OC(=O)N1CCN(c2cccc3[nH]ccc23)CC1
4-(4-boc-piperazinyl)-indole
O=S(=O)(Cl)c1cccc2ccccc12
naphthylsulfonylchloride
→
Cl.O=S(=O)(c1cccc2ccccc12)n1ccc2c(N3CCNCC3)cccc21
title compound
Cl.O=S(=O)(c1cccc2ccccc12)n1ccc2c(N3CCNCC3)cccc21
1-(1-Naphthylsulfonyl)-4-(1-piperazinyl)-1H-indole Hydrochloride

Réactifs

CC(C)(C)OC(=O)N1CCN(c2cccc3[nH]ccc23)CC1
4-(4-boc-piperazinyl)-indole
O=S(=O)(Cl)c1cccc2ccccc12
naphthylsulfonylchloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound was prepared according 4-(4-boc-piperazinyl)-indole and naphthylsulfonylchloride according to Method 3: 1H NMR (270 MHz, DMSO-d6) δ 9.03 (br, 1 H), 8.63 (d, J=8 Hz, 1 H), 8.43 (d, J=8 Hz, 1 H), 8.34 (d, J=8 Hz, 1 H), 8.15–8.05 (m, 2 H), 7.80–7.65 (m, 3 H), 7.41 (d, J=8 Hz, 1 H), 7.18 (t, J=8 Hz, 1 H), 6.93 (d, J=5Hz, 1 H), 6.74 (d, J=8Hz, 1 H), 3.30–3.20 (m, 8 H); MS (ESI+) for m/z 392 (M+H)+.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07087750B2uspto-grants-2006_08