Réaction #84092
ord-19c4ea5a67824c7ca1dab9e0753361c9
Équation de réaction
Water
TMSN3
4-(6-methoxyquinolin-2-yl)benzothioamide
oxalylchloride
→
product
Rendement 78.0%
5-(4-(6-methoxyquinolin-2-yl)phenyl)-1,2,4-thiadiazol-3(2H)-one
Rendement 78.0%
Réactifs
Aucun
Conditions de réaction
Température
90°CELSIUS
Conditions détaillées
See reaction.notes.procedure_details.
Traitement
- 1FiltrationThe mixture was filtered
Mode opératoire
To a solution of 4-(6-methoxyquinolin-2-yl)benzothioamide (500 mg, 1.07 mmol) in DCE (10 mL) was added oxalylchloride (0.3 mL, 3.9 mmol) dropwise at 0° C. The mixture was heated to 90° C. for 2 hours. TMSN3 (0.8 mL, 5.7 mmol) was added dropwise. The mixture was stirred at 100° C. for 2 hours. Water (10 mL) was added to the mixture. The mixture was filtered and the filter cake was washed with IPA (20 mL) to product (280 mg, yield 49%).