Réaction #84083

Équation de réaction

Water

4-(6-methoxyquinolin-2-yl)benzonitrile

hydroxylamine hydrochloride

K2CO3

→

product

N-hydroxy-4-(6-methoxyquinolin-2-yl)benzimidamide

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture was refluxed for 12 hours
2. 2
   Filtrationthe precipitated solid was collected by filtration
3. 3
   Lavagewashed with ethanol (5 mL)
4. 4
   Autredried over high vacuum

Mode opératoire

Scheme 4, route B, step 1: 4-(6-methoxyquinolin-2-yl)benzonitrile (prepared via scheme 3) (780 mg, 3.00 mmol) was suspended in methanol (10 mL) and hydroxylamine hydrochloride (639 mg, 10.7 mmol), K2CO3 (414 mg, 3.00 mmol) were added. The reaction mixture was refluxed for 12 hours. Water (15 mL) was added and the precipitated solid was collected by filtration, washed with ethanol (5 mL) and dried over high vacuum to give the product (600 mg).

Source