Réaction #84081

Équation de réaction

4-(4-chloro-6-methoxyquinolin-2-yl)benzonitrile

CsF

→

desired product

Rendement 31.7%

4-(4-fluoro-6-methoxyquinolin-2-yl)benzonitrile

Rendement 31.7%

Solvants

DMSO

Conditions de réaction

Traitement

1. 1
   AutreAn aqueous/EtOAC workup was followed by purification by column chromatography (PE/EA=10/1)

Mode opératoire

A mixture of 4-(4-chloro-6-methoxyquinolin-2-yl)benzonitrile (Seem Example 11, step 1) (1 g, 3.4 mmol), CsF (5.2 g, 34 mmol), and n-Bu4NBr (109 mg, 0.34 mmol) in DMSO (10 mL) was heated to 150° C. for 2 h. An aqueous/EtOAC workup was followed by purification by column chromatography (PE/EA=10/1) to afford desired product (300 mg, 31.7%).

Source