Réaction #84080

ord-8f2805214c4840e693416824c0cb1a4b

Équation de réaction

CC(C)(C)OC(=O)NNC(=O)c1ccc(-c2ccc3cc(O)ccc3n2)cc1
tert-butyl 2-(4-(6-hydroxyquinolin-2-yl)benzoyl)hydrazinecarboxylate
→
NNC(=O)c1ccc(-c2ccc3cc(O)ccc3n2)cc1
product
Rendement 68.0%
NNC(=O)c1ccc(-c2ccc3cc(O)ccc3n2)cc1
4-(6-hydroxyquinolin-2-yl)benzohydrazide
Rendement 68.0%

Réactifs

CC(C)(C)OC(=O)NNC(=O)c1ccc(-c2ccc3cc(O)ccc3n2)cc1
tert-butyl 2-(4-(6-hydroxyquinolin-2-yl)benzoyl)hydrazinecarboxylate

Réactifs

Aucun

Solvants

CO.Cl
HCl MeOH

Conditions de réaction

Température
25°CELSIUS
Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    ConcentrationThe resulting mixture was concentrated under reduced pressure to dryness

Mode opératoire

A mixture of tert-butyl 2-(4-(6-hydroxyquinolin-2-yl)benzoyl)hydrazinecarboxylate (240 mg, 0.633 mmol) and HCl/MeOH (20 mL, 4M) was stirred at 25° C. overnight. The resulting mixture was concentrated under reduced pressure to dryness to give the product (120 mg, yield 68%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US09433618B2uspto-grants-2016_09