Réaction #84069

Équation de réaction

4-(6-hydroxyquinolin-2-yl)benzonitrile

NH2OH.HCl

→

desired product

Rendement 78.0%

N-hydroxy-4-(6-hydroxyquinolin-2-yl)benzimidamide

Rendement 78.0%

Solvants

EtOH

Conditions de réaction

Traitement

1. 1
   Concentrationfollowed by concentration in vacuo
2. 2
   workup.STIRRINGstirred for 1 hour
3. 3
   FiltrationFiltration
4. 4
   Autredrying of the solids

Mode opératoire

See Scheme 4, route B. 4-(6-hydroxyquinolin-2-yl)benzonitrile (900 mg, 3.68 mmol) was dissolved in 25 mL of EtOH and to it was added NH2OH.HCl (500 mg, 7.36 mmol) and TEA (1.5 mL). The mixture was stirred at 80° C. for 2 hours followed by concentration in vacuo. The crude solids were then suspended in 25 mL of H2O and stirred for 1 hour. Filtration and drying of the solids yielded desired product (800 mg, 78% yield).

Source