Réaction #84066

Équation de réaction

4-cyanophenylboronic acid

2,4-dichloro-6-methoxyquinoline

→

desired product

4-(4-chloro-6-methoxyquinolin-2-yl)benzonitrile

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   Températureto cool
2. 2
   AutreThe resulting solid was isolated by filtration
3. 3
   Lavagewashed with water
4. 4
   Autredried
5. 5
   Autrefollowed by recrystallization from methanol

Mode opératoire

Followed Scheme 2, Step 1 starting from 4-cyanophenylboronic acid and 2,4-dichloro-6-methoxyquinoline, where the solvent used was DMF, and the catalyst used was Pd(PPh3)4. The mixture was heated to 100° C. for 3 h, allowed to cool, and then poured into ice water. The resulting solid was isolated by filtration, washed with water, and dried followed by recrystallization from methanol to give the desired product.

Source