Réaction #84049

Équation de réaction

methyl 6-bromo-1-benzothiophene-2-carboxylate

potassium hydroxide

→

desired product

6-Bromo-1-benzothiophene-2-carboxylic acid

Solvants

THF

Conditions de réaction

Traitement

1. 1
   AutreThe solvent is removed in vacuo
2. 2
   FiltrationThe resulting precipitate is filtered off with suction
3. 3
   Lavagewashed with water
4. 4
   Autredried in vacuo at 50° C

Mode opératoire

A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50° C. 3.55 g (93.5% of theory) of the desired product are obtained.

Source